Closing out a successful resupply mission, two Discovery astronauts, operating the International Space Station's robot arm, detached a cargo module from the lab complex late Monday and returned it to the shuttle's cargo bay for the trip back to Earth Thursday.

One orbit later, the seven shuttle fliers bid farewell to the station's six-person crew and floated back into Discovery for the last time, setting the stage for undocking Tuesday afternoon.

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The shuttle and station crews are gathering in the Harmony module for a farewell ceremony. The Discovery astronauts will be heading back to the orbiter and closing the hatchway in preparation for tomorrow's undocking.

The flight plan calls for the shuttlte crew to spend the night on their own spacecraft with the hatches already shut so that when wakeup occurs tomorrow they can get right into the departure activities. It will be a busy day, not only with undocking but also a final round of heat shield inspections tomorrow night.

Leonardo is back in the payload bay and latched in place for the journey home to Kennedy Space Center later this week.

The Italian-made reusable module, making its sixth trip to the space station, delivered fluid and materials science experiment racks, a laboratory freezer to store samples, another sleep compartment for the station's larger resident crews, a new air purification system, the treadmill named for comedian Stephen Colbert and extensive amount of supplies and logistics

After Leonardo was emptied, stuff needing a ride back to the ground and no-longer-used equipment were stowed into the module.

Leonardo is being lined up for final insertion into the bay.

Anchored on the end of the space station's robotic arm, the Leonardo module is undergoing a quarter roll to the proper orientation for entering the payload bay.

After seven days being attached to the International Space Station for the unloading its 13,898 pounds of cargo and subsequent packing of 2,412 pounds of items for return to Earth, the Leonardo module has been unberthed from the nadir port of the Harmony connecting node. The module will be put back into the payload bay of Discovery for the ride home.

The latches have opened, leaving Leonardo in the hand of the robot arm to back away from the station.

All 16 bolts have been disengaged.

Commands are being sent to drive open the bolts that have held Leonardo to the space station.

Depressurization of the vestibule and leak checks between Leonardo and its berthing port on the Harmony node have been completed.

The arm has a firm grasp on Leonardo. The astronauts will oversee the release of 16 electrically-driven bolts and capture latches that have kept the module structurally attached to the station. Once that work is finished, then Leonardo will be free to separate away.

The International Space Station's robot arm is moving toward the grapple fixture on Leonardo. The arm will do the heavy lifting this evening to remove the module and maneuver it down into the shuttle's cargo bay.

Work inside the Leonardo module has been completed for the mission. The hatch was just closed and locked.

The station's robot arm will grapple the module in a few hours for its berthing back in the space shuttle payload bay.

The Discovery astronauts plan to detach the Leonardo cargo module from the International Space Station today and berth it in the shuttle's cargo bay for return to Earth. After a late-night farewell ceremony, hatches between the shuttle and station will be closed, setting the stage for undocking Tuesday.

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Flight Day 11's wakeup music has played for the astronauts, beginning a day that will see the joint shuttle and station crews close up the Leonardo, detach it from the Harmony node and berth the reusable cargo-delivery module to Discovery's payload bay. Then later tonight, the crews will say their farewells to each other and close the hatchway in preparation for Tuesday's departure of the space shuttle.

The latest version of the NASA Television schedule (Rev. L) can be downloaded here.

A vaccine to protect people against Salmonella, a deadly bacteria that often contaminates food processing operations, is headed for human testing following commercial development in zero gravity on the space shuttle and International Space Station.

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A chart showing Tuesday's undocking timeline can be seen here.

The shuttle Discovery astronauts have begun their half-day off-duty time. Bed time is scheduled for 3:29 a.m. EDT.

At the robotics workstation, the astronauts are performing a complex process of moving the International Space Station's robot arm. It involves several relocations of the inch-worm arm in order to get the desired end positioned on the Harmony module in preparation for grabbing the Japanese HTV cargo spacecraft in a couple of weeks.

For those keeping score at home, here's a look at the latest numbers on the amount of cargo being transferred between Discovery and the International Space Station during this mission:

• 18,548 pounds of supplies, new hardware and water delivered to the space station by the shuttle, including 13,898 pounds unloaded from the Leonardo module, some 1,705 pounds of equipment brought up in Discovery's middeck, the 1,702-pound ammonia tank assembly installed by the spacewalkers and 1,243 pounds of water generated aboard the shuttle and moved over in bags.
  
  
• 5,223 pounds of station hardware will be returned to Earth aboard the shuttle, including 2,412 stowed inside Leonardo, 1,950 pounds for the old ammonia tank and external experiments removed by the spacewalkers and 861 pounds of items placed in Discovery's middeck.

Sailing into the home stretch of a busy space station resupply mission, the Discovery astronauts worked Sunday to wrap up equipment and supply transfers before enjoying a half day off to relax and enjoy the view.

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The Flight Day 10 wakeup call has been received by the shuttle Discovery crew. More transfer work and packing up the Leonardo module are the prime chores today, along with some off-duty time later tonight.

Read our earlier status center coverage.